COLLAGEN-BINDING HYBRID POLYPEPTIDE

摘要

A collagen-binding hybrid polypeptide wherein the collagen-binding ability is imparted to a functional polypeptide is provided. The hybrid polypeptide is obtained by ligating a collagen-binding domain having an amino acid sequence which constitutes the polypeptide in human fibronectin from Ala <260> to Arg <484> to the functional polypeptide by a genetic engineering technique. The collagen-binding hybrid polypeptide is useful in a drug delivery system (DDS) for the functional polypeptide. Moreover, this polypeptide can be formulated into a complex together with collagen. The functionally modified collagen matrix thus obtained is useful as a new biomaterial for tissue regeneration.