发明名称 |
NOVEL NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE DERIVATIVES CONTAINING THESE ANALOGS |
摘要 |
Nucleoside analogues expressed by the following general formula <CHEM> where B represents an aromatic base having carbonyl oxygen at the 2-position, or a 2-hydroxyphenyl group, or oligonucleotide derivatives containing one or more of the nucleoside analogues are provided. The oligonucleotide derivatives are triplex-forming oligonucleotide derivatives which bind specifically to target double-stranded DNA with high affinity in the antigene method to form triplexes, and can thereby control and inhibit the expression of relevant genes efficiently, and which show high resistance to nucleases.
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申请公布号 |
EP1314734(A1) |
申请公布日期 |
2003.05.28 |
申请号 |
EP20010961147 |
申请日期 |
2001.08.29 |
申请人 |
IMANISHI, TAKESHI |
发明人 |
IMANISHI, TAKESHI;OBIKA, SATOSHI |
分类号 |
C07H19/04;C07H19/048;C07H21/00;(IPC1-7):C07D493/04 |
主分类号 |
C07H19/04 |
代理机构 |
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