PROCESS FOR PREPARING CHIRAL 2,2-DIMETHYL CYCLOPROPANE CARBOXYL DERIVATIVES

摘要

PURPOSE: A process for preparing chiral 2,2-dimethyl cyclopropane carboxyl derivatives is provided, high purity of chiral 2,2-dimethyl cyclopropane carboxyl derivatives can be easily mass-produced by using a chiral hetero ring compound of formula 3 as a beam splitter. CONSTITUTION: The process for preparing chiral 2,2-dimethyl cyclopropane carboxyl derivatives of the formula(1) comprises the steps of: reacting (RS)-2,2-dimethyl cyclopropane carbonic acid(2) with a beam splitter to prepare a partial stereoisomer; and separating the partial stereoisomer by using crystallization or chromatography to prepare (R)-2,2-dimethyl cyclopropane carboxyl derivatives(1a) and (S)-2,2-dimethyl cyclopropane carboxyl derivatives(1b), wherein the beam splitter is the chiral hetero ring compound of formula(3); X is O or S; Y is O, S or N-R5; R5 is C1-C6 alkyl, or C1-C6 alkoxy or halogen substituted or unsubstituted aryl; R1, R2, R3 and R4 are independently H, C1-C6 alkyl, C1-C6 alkoxy or halogen substituted or unsubstituted aryl, or R6-O-CH2; and R6 is C1-C6 alkyl, or C1-C6 alkoxy or halogen substituted or unsubstituted aryl.