| 摘要 |
PURPOSE: Provided is a method of preparing a diclofenac-based acrylic adhesive by polymerizing a hydroxyl group and a carboxyl group with an adhesive polymer as a main component to improve blending stability with added drugs and delivery of drugs to the skin. Therefore, the product has improved therapeutic effect and is useful as a medical patch. CONSTITUTION: An acrylic adhesive is prepared by mixing an acrylic copolymer with a basic organic salt in an equivalence ratio of 0.8 to 1.1 and then esterifying at low temperature(50 to 8deg.C) for 30min or more. The acrylic copolymer contains 8 to 15% by weight of a mixed dissolution content comprising acrylic acid, methacrylic acid, maleic anhydride, fumaric acid and itaconic acid of vinyl-based monomers containing unsaturated carboxyl groups.
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