发明名称 |
Modified adenoviral fiber and target adenoviruses |
摘要 |
The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragment, and expression vector, and a cell line expressing said fiber, and also concerns an adenovirus, the process for producing this type of adenovirus, and a infectable host cell, as well as their therapeutic application and a corresponding pharmaceutical composition.
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申请公布号 |
US6569677(B1) |
申请公布日期 |
2003.05.27 |
申请号 |
US19990402401 |
申请日期 |
1999.10.04 |
申请人 |
TRANSGENE S.A.;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
LEGRAND VALERIE;MEHTALI MAJID;BOULANGER PIERRE |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K38/27;A61K38/28;A61K38/43;A61K38/55;A61K39/395;A61K48/00;C07K14/075;C12N5/10;C12N7/00;C12N15/34;C12N15/861;(IPC1-7):C12N15/861;C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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