| 摘要 |
PURPOSE: Provided is a method of preparing solid dispersions with poorly water soluble drugs, substituted cyclodextrin and a water free organic solvent. The pharmaceutical composition containing the solid dispersions improves the dissolution rate of poorly water soluble drugs and thus maximizes bioavailability. CONSTITUTION: Poorly water soluble drugs except for itraconazole and saperconazole, and cyclodextrin containing a substituent are dissolved in a water free organic solvent and dried by a vacuum drying method or a spray drying method to produce solid dispersions. The solid dispersions contain 0.1 to 10 parts by weight of substituted cyclodextrin, based on 1 part by weight of poorly water soluble drugs. The poorly water soluble drugs are one ore more selected from the group consisting of ibuprofen, S-ibuprofen, ketoprofen, piroxicam, ketoconazole, domperidone, docetaxel, paclitaxel, acyclovir and sodium alendronate.
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