NOVEL METHOD FOR MANUFACTURING (1)3-HALOMETHYL-3-CEPHEM-4-CARBOXYLATE 1-OXIDE

摘要

PURPOSE: Provided is a novel method for manufacturing (1)3-halomethyl-3-cephem-4-carboxylate 1-oxide which is a useful intermediate in manufacturing cephalosporin antibiotics. CONSTITUTION: A novel method for manufacturing nitrobenzyl 7-phenoxyacetamido-3-halomethyl-3-cephem-4-carboxylate 1-oxide represented by the formula(1) comprises reacting a compound of the formula(II) with triethylenediamine represented by the formula(II) and peracetic acid in the presence of a halogenating agent.