发明名称 |
Recombinant antibody fragments as autoantibody antagonists |
摘要 |
The invention provides methods and compositions for inhibiting autoantibody binding in demyelinating disease such as multiple sclerosis. The compositions comprise immunoglobulin CDR3 sequences derived from combinatorial phage display libraries selected for high-affinity binding to myelin oligodendrocyte glycoprotein.
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申请公布号 |
US6569431(B2) |
申请公布日期 |
2003.05.27 |
申请号 |
US20010899896 |
申请日期 |
2001.07.05 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
VON BUEDINGEN HANS-CHRISTIAN;GENAIN CLAUDE P.;HAUSER STEPHEN L. |
分类号 |
A61K38/00;A61P25/00;A61P37/02;C07K16/18;(IPC1-7):A61K39/395;C07K16/28 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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