发明名称 |
Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains |
摘要 |
Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even staphylococci that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include beta-lactams and glycopeptides.
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申请公布号 |
US6569830(B1) |
申请公布日期 |
2003.05.27 |
申请号 |
US19990263776 |
申请日期 |
1999.03.05 |
申请人 |
AMBI, INC. |
发明人 |
CLIMO MICHAEL;MURPHY ELLEN;ARCHER GORDON |
分类号 |
A61K45/06;(IPC1-7):A61K38/00;A61K38/16;A61K38/48 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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