发明名称 |
Prostate-specific membrane antigen and uses thereof |
摘要 |
This invention provides an isolated nucleic acid molecule encoding an alternatively spliced human prostate-specific membrane antigen. This invention provides an isolated nucleic acid comprising a promoter sequence normally associated with the transcription of a gene encoding a human prostate-specific membrane antigen. This invention provides an isolated polypeptide having the biological activity of an alternatively spliced prostate-specific membrane antigen. This invention provides a method of detecting a nucleic acid encoding an alternatively spliced human prostate-specific membrane antigen and a method of detecting a prostate tumor cell in a subject. Lastly, this invention provides a pharmaceutical composition comprising a compound in a therapeutically effective amount and a pharmaceutically acceptable carrier and a method of making prostate cells susceptible to a cytotoxic chemotherapeutic agent.
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申请公布号 |
US6569432(B1) |
申请公布日期 |
2003.05.27 |
申请号 |
US19960705477 |
申请日期 |
1996.08.29 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
ISRAELI RON S.;HESTON WARREN D. W.;FAIR WILLIAM R.;OUERFELLI OUATHEK;PINTO JOHN |
分类号 |
C07K14/705;C12Q1/68;(IPC1-7):A61K39/00 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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