发明名称 |
Enteric coated pharmaceutical tablet and method of manufacturing |
摘要 |
A high drug load enteric coated pharmaceutical composition is provided which includes a core in the form of a tablet and which is comprised of a medicament which is sensitive to a low pH environment of less than 3, such as ddl, and having an enteric coating formed of methacrylic acid copolymer and a plasticizer. The tablets may be of varying sizes and may be orally ingested individually or a plurality of tablets sufficient to attain a desired dosage may be encapsulated in a dissolvable capsule. The tablets have excellent resistance to disintegration at pH less than 3 but have excellent drug release properties at pH greater than 4.5. A novel method of making said pharmaceutical composition is also disclosed.
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申请公布号 |
US6569457(B2) |
申请公布日期 |
2003.05.27 |
申请号 |
US20010866501 |
申请日期 |
2001.05.25 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
ULLAH ISMAT;WILEY GARY J. |
分类号 |
A61K9/36;A61K9/20;A61K9/28;A61K9/30;A61K9/32;A61K9/48;A61K9/52;A61K9/54;A61K9/62;A61K31/22;A61K31/522;A61K31/704;A61K31/7048;A61K31/708;A61K38/46;A61K47/32;A61K47/36;A61K47/38;A61P31/12;(IPC1-7):A61K9/32 |
主分类号 |
A61K9/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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