| 摘要 |
<p>The present invention relates to an improved method for synthesis of mycophenolate mofetil by reacting mycophenolic acid with an excess of 2-morpholino ethanol using an enzyme as catalyst in a water-free organic solvent and its subsequent purification. The use of an anhydrous organic solvent leads to higher conversion of mycophenolic acid. Water generated in the reaction may also be removed using molecular sieves to further improve conversion of mycophenolic acid to mycophenolate mofetil.</p> |
