AZABICYCLO COMPOUND, MATRIX METALLOPROTEASE INHIBITOR, AND SKIN PREPARATION

摘要

An azabicyclo compound (I) or a salt thereof which each has excellent inhibitory activity against matrix metalloproteases (MMPs) and is useful in medicinal compositions, cosmetic compositions, and skin preparations. In the formula (I), R represents hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, acyl, COOR1, carbamoyl, or SO2R2 (R1 and R2 each is alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl); X represents methylene, ethylene, or propylene; and …… indicates a single bond or double bond.