| 摘要 |
A first bispecific antibody molecule comprises at least one binding site wit h a variable domain on a light chain (V<SB>L</SB>) and a variable domain for the T-cell receptor CD-28, linked thereto on a heavy chain (Vh). The antibody molecule further comprises at least one binding site with a variable domain on a heavy chain (V<SB>H</SB>) and a variable domain for a tumour a ntigen, linked thereto on a light chain (V<SB>L</SB>). The variable domains on the heavy chains for both specificities are connected to each other by means of a peptide linker. A second bispecific antibody molecule is bivalent for CD-28 and at least monovalent for the tumour antigen.
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