发明名称 |
METHODS FOR PREVENTING OR TREATING DISEASE MEDIATEB BY TOXIN-SECRETING BACTERIA |
摘要 |
Methods and pharmaceutical compositions for preventing and treating disease mediated by toxin-secreting bacteria. Inventive methods and compositions are suited to preventing or treating infections caused by bacterial toxins that enter host cells via receptor-mediated endocytosis (e.g., the anthrax and diphtheria toxins). Methods comprise a step of administering to an individual a pharmaceutical composition that includes an effective amount of an inhibitor of endosomal acidification. The inhibitor may be a primary amine, a carboxylic ionophore, or a selective inhibitor of the vacuolar proton pump (V-ATPase). The inhibitors of endosomal acidification may be employed in combination with other therapeutics such as antibiotics and antitoxins in order to prevent, treat or cure the disease.
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申请公布号 |
WO03041710(A1) |
申请公布日期 |
2003.05.22 |
申请号 |
WO2002US36472 |
申请日期 |
2002.11.13 |
申请人 |
PANACEA PHARMACEUTICALS, LLC;CAPLAN, MICHAEL, J. |
发明人 |
CAPLAN, MICHAEL, J. |
分类号 |
A61K31/165;A61K31/43;A61K31/4706;A61K31/496;A61K31/545;A61K31/546;A61K31/65;A61K31/7048;A61P31/04;(IPC1-7):A61K31/470;A61K31/704 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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