SYSTEM AND METHOD OF DETERMINING PROTEOMIC DIFFERENCES

摘要

The present invention relates to a system and methods for identifying differential peptide expression in one or more peptide populations. Each population 109 is labeled with a discernable label and provides a mechanism to resolve mixed peptide populations 130 using mass spectroscopy-based techniques. Spectra 146 produced by the peptide sample are used to interrogate a spectral database in which peptide sequences of known spectra are stored. In addition to providing sequence information, the methods presented herein may be used to determine qualitative and quantitative measurements of peptide expression. These measurements may further be used to determine proteomic differences and novel peptide expression.