NOVEL PROMOTERS INDUCIBLE BY DNA DAMAGING CONDITIONS OR AGENTS AND USES THEREOF

摘要

The present invention relates a method of converting a promoter into a promoter which is inducible upon genotoxic compounds or conditions. The present invention further relates to a method of reducing the basal expression level of promoter which is inducible upon genotoxic compounds or conditions. These methods provides novel nucleotide sequences, vectors and host cells for the expression of proteins under the control of genotoxic conditons or compounds. The novel expression system has wide industrial applications into the field of recombinant protein production but has also clinical applications such as the controlled expression of therapeutic compounds in hypoxic tissues such as tumors.