发明名称 |
Transgenically produced antithrombin III |
摘要 |
This invention relates to transgenically produced human Antithrombin III (tgATIII). The human ATIII produced by the transgenic process of the present invention has a monosaccharide composition which comprises N-acetylgalactosamine (GalNAc) along with fucose, N-acetylglucosamine, galactose, mannose, and N-acetylneuraminic acid/N-glycolyneuraminic acid. The monosaccharide composition differs with that of plasma derived ATIII (phATIII). It has been found that tgATIII has an increased clearance rate when compared to phATIII.
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申请公布号 |
US2003096974(A1) |
申请公布日期 |
2003.05.22 |
申请号 |
US20020188658 |
申请日期 |
2002.07.02 |
申请人 |
GENZYME TRANSGENICS CORPORATION, A MASSACHUSETTS CORPORATION |
发明人 |
DITULLIO PAUL;MEADE HARRY M.;COLE EDWARD S. |
分类号 |
A61K38/00;C07K14/81;(IPC1-7):C07K14/475;C12N9/64 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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