THREE-DIMENSIONAL STRUCTURE OF PROSTAGLANDIN D SYNTHASE AND UTILIZATION THEREOF

摘要

It is intended to provide a method of designing an antiallergic agent, a sle ep controlling agent, an antiobestic and a remedy for brain injury acting via t he inhibition of the biosynthesis of prostaglandin D2. Crystals of a complex of human-origin hematopoietic prostaglandin D synthase, glutathione and a substrate analog or an inhibitor, etc. are prepared and the three-dimensiona l structural coordinate of each atom in the complex is determined by X-ray crystal analysis.