A conjugate exhibiting interferon beta activity and comprising at least one first non-polypeptide moiety covalently attached to an interferon beta polypeptide, the amino acid sequence of which differs from that of wildtype human interferon beta in at least one introduced and at least one removed amino acid residue comprising an attachment group for said first non-polypeptide moiety. The first non-polypeptide moiety is e.g. a polymer molecule or a sugar moiety. The conjugate finds particular use in therapy.
申请公布号
WO0115736(A3)
申请公布日期
2003.05.22
申请号
WO2000DK00471
申请日期
2000.08.25
申请人
MAXYGEN APS
发明人
PEDERSEN, ANDERS, HJELHOLT;SCHAMBYE, HANS, THALSGAARD;ANDERSEN, KIM, VILBOUR;BORNAES, CLAUS;RASMUSSEN, POUL, BAAD