The invention relates to the modification of antibodies reactive to human tumor necrosis factor alpha (TNF alpha) to result in anti-TNF alpha antibodies that are substantially non-immunogenic or less immunogenic than any non-modified parental antibody when used in vivo. The invention relates also to peptide molecules comprising T-cell epitopes of the V-regions of the parental antibody which are modified by amino acid alteration in order to reduce or eliminate said T-cell epitopes.
申请公布号
WO03042247(A2)
申请公布日期
2003.05.22
申请号
WO2002EP12566
申请日期
2002.11.11
申请人
MERCK PATENT GMBH;HELLENDOORN, KOEN;BAKER, MATTHEW;CARR, FRANCIS, J.
发明人
HELLENDOORN, KOEN;BAKER, MATTHEW;CARR, FRANCIS, J.