Schicht mit selektiv perfluorierter Oberfläche

摘要

The present invention concerns new methods for producing substrates with surfaces, that are covalently linked to at least one type of hapten or biological macromolecule, with reduced non−specific biological macromolecule adsorption. In another aspect, the invention concerns substrates with surfaces that are covalently linked to at least one type of hapten, showing reduced non−specific interactions with circulating compounds and the use of these substrates for the quantitative detection of at least one type of hapten−specific biological macromolecule receptor, in particular a hapten−specific antibody, in a test probe. Further, the invention concerns substrates with surfaces that are covalently linked to at least one type of biological macromolecule, in particular one type of antibody, showing reduced non−specific interactions with circulating compounds and the use of these substrates for the quantitative detection of at least one type of hapten in a test probe. In another aspect, the invention is related to specific thiols of formula (A) and disulphides of formula (B), where the variables are as defined in the claims, which can be used for producing the above−mentioned substrate surfaces. The invention is further related to the use of these specific thiols and disulfides for producing substrates with surfaces that are covalently linked to at least one type of hapten or to at least one type of biological macromolecule, showing reduced non−specific interactions with circulating compounds.