SEARCH METHOD FOR PRION-PROTEIN-STRUCTURE TRANSFORMATION INHIBITOR

摘要

PROBLEM TO BE SOLVED: To provide a search method for a prion-protein-structure transformation inhibitor. SOLUTION: The search method for the prion-protein-structure transformation inhibitor contains a process (a) in which a candidate substance to be bonded to a prion peptide composed of an amino acid sequence indicated in Sequence No.1 is selected from a specimen, a process (b) in which the bonding selectivity to the prion peptide of the selected candidate substance is selected, and a process (c) in which the inhibition effect with reference to the transformation to an abnormal prion from a normal prion of the candidate substance adapted to its evaluation is verified.