摘要 |
PROBLEM TO BE SOLVED: To produce the subject compound easy in supplying its raw material and useful for producing medicines, etc., with a slight production of by-products, and high in purity and yield, by reacting a specific iodinated aromatic compound with a specified compound in the presence of copper bromide, etc., and trifluoromethylating the iodine atoms. SOLUTION: An iodinated aromatic compound in which iodine atoms are bonded to one or more carbon atoms forming an aromatic ring such as a compound represented by formula I or II (n) is 1-6; (m) is 0-5; [(m)+(n)] is 6; R2 is H, a 1-5C alkyl or the like; (k) is 1-4; (p) is 0-3; [(k)+(p)] is 4; R3 is R2} is reacted with a compound represented by the formula FSO2CF2COOR1 (R1 is a 1-5C alkyl) in the presence of copper (I) bromide and 1-methyl-2-pyrrolidone to trifluoromethylate the iodine atoms. Thereby, a trifuloromethylated aromatic compound such as a compound represented by formula III or IV is produced. |