| 摘要 |
(1) Distannous salts of gem-diphosphonic acids of the formula:- wherein R1 is H, halogen, OH, benzyl, alkyl, hydroxyalkyl, methoxyalkyl or carboxyalkyl and has up to 12 c atoms; and R2 is H, halogen, OH, acetyl, phenyl, benzyl, alkyl, hydroxyalkyl, methoxyalkyl or carboxyalkyl and has up to 12 C atoms; and (2) an oral composition for caries prophylaxis comprising from 0.05% to 5% by wt. of at least one of the foregoing distannous salts and at least one water-soluble fluoride in a sufficient quantity to provide from 25 to 4000 parts of fluoride ion per million parts by wt. of the composition. The compositions provide both improved anticaries and anticalculus effects. Distannous methane diphosphonate and distannous ethane-1-hydroxy-1, 1-diphosphonate. |
