发明名称 |
DNA encoding a vertebrate homolog of hedgehog, Vhh-1, expressed by the notochord, and uses thereof |
摘要 |
This invention provides an isolated nucleic acid molecule encoding a vhh-1 protein, an isolated protein which is a vhh-1 protein, vectors comprising an isolated nucleic acid molecule encoding a vhh-1 protein, mamunalian cells comprising such vectors, antibodies directed to a vhh-1 protein, nucleic acid probes useful for detecting a nucleic acid molecule encoding a vhh-1 protein, pharmaceutical compositions related to the vhh-1 proteins, nonhuman transgenic animals which express a normal or a mutant vhh-1 protein. This invention further provides methods for inducing differentiation of floor plate cell, motor neuron, generating ventral neurons and treatments for alleviating abnormalities associated with the vhh-1 protein.
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申请公布号 |
US6566092(B1) |
申请公布日期 |
2003.05.20 |
申请号 |
US19970700393 |
申请日期 |
1997.02.27 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
JESSELL THOMAS M.;DODD JANE;ROELINK HENK;EDLUND THOMAS |
分类号 |
A01K67/027;A61K38/00;A61P25/00;C07H21/04;C07K14/435;C07K14/46;C07K14/475;C07K14/48;C07K16/22;C12N5/0793;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12Q1/68;(IPC1-7):C12N15/12;C12N5/00;C12P21/06 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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