| 摘要 |
FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to the field of synthesis and technology for preparing 6-methyluracil-5-sulfochloride as perspective substance in production of medicinal preparations and dyes. Method is performed by successive interaction of the parent 6-methyluracil with chlorosulfonic acid at 80-90 C and the following treatment with phosphorus trichloride at temperature 40-63 C in the presence of catalytic amount of dimethyl- formamide from 0.081 to 0.163 mole per 1 mole of 6-methyluracil. Reaction mass is diluted with 90-96 wt.% ethyl alcohol at temperature 0-10 C and the end product is isolated. Invention provides the increased yield of end product, enhanced technological effectiveness of process and expanded raw base in sulfochlorination reaction process. EFFECT: improved method of synthesis. 1 tbl, 5 ex |
