| 摘要 |
FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to novel compounds of the formula (I) and (II) that elicit antifungal activity in vitro against fungal microorganisms including cutaneous hyphomycetes, for example, Epidermophyton, Microsporum, Trichophyton, Sporothrix schenckii, Aspergillus or Candida. Compounds of formulas (I) and (II) show antifungal activity in vitro in concentrations 1-100 mcg/ml. In formulas (I) and (II) values R1, R2, R4 are similar or different and mean C1-C5-alkoxy-group; R3 means hydrogen atom or C1-C10-alkyl; A- means inorganic acid ion, organic acid ion or halide; R5 means hydrogen atom, pyridylmethyl, substituted pyridylmethyl or group of the formula (XI) where Z1, Z2, Z3, Z4, Z5 are similar or different and mean independently each of other hydrogen, halogen atom, C1-C5-alkyl, trifluoromethyl, phenyl, substituted phenyl, nitro-group, C1-C4-alkoxy-group, trifluoromethoxy-group, hydroxy-group, phenoxy-group, vinyl-group, methoxycarboxyl-group. EFFECT: improved preparing methods, valuable medicinal properties of compounds. 19 cl, 5 tbl
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