| 摘要 |
<p>The invention relates to a pharmaceutical composition and a dosage form for treating incontinence with oxybutynin and a second drug. The aforementioned drug substance can be any drug that is used to treat incontinence. The dosage form can include, independently, therapeutic or subtherapeutic quantities of oxybutynin and the second drug, depending on the administration method, the dosage form employed and the second drug used. Particular configurations of said composition include a dosage form that releases oxybutynin and the second drug in a controlled manner in order to maintain effective therapeutic levels of oxybutynin and/or the second drug in a mammal for an extended period of time. According to the invention, an osmotic device is provided which comprises a double-layer core. The aforementioned osmotic device provides dual controlled release of both drugs from the core. The invention also relates to a method of treating urinary incontinence (stress or emergency) with a pharmaceutical composition and a dosage form. The combination of the oxybutynin and the second drug provides an improved general clinical benefit in relation to all other agents which are administered alone, with approximately the same dose.</p> |
