| 发明名称 |
PYRAZOLE DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS |
| 摘要 |
Compounds of the formula (I) and salts and solvates thereof, in which X, R<1>, R<2>, R<3>, R<4> and R<5> are as defined in Claim 1, are suitable as glycine transporter inhibitors and can be used in human and veterinary medicine for the prophylaxis and treatment of schizophrenia, depression, dementia, Parkinson's disease, Alzheimer's disease, Lewy bodies dementia, Huntington's disease, Tourette's syndrome, anxiety, learning and memory restrictions, neurodegenerative disorders and other cognitive impairments, as well as nicotine dependence and pain.
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| 申请公布号 |
WO03031435(A8) |
申请公布日期 |
2003.05.15 |
| 申请号 |
WO2002EP10172 |
申请日期 |
2002.09.11 |
| 申请人 |
MERCK PATENT GMBH;YAMANOUCHI PHARMACEUTICAL CO. LTD.;SCHIEMANN, KAI;ARLT, MICHAEL;FINSINGER, DIRK;ACKERMANN, KARL-AUGUST;RAUTENBERG, WILFRIED;LEIBROCK, JOACHIM;GREINER, HARTMUT;TOBE, TAKAHIKO |
发明人 |
SCHIEMANN, KAI;ARLT, MICHAEL;FINSINGER, DIRK;ACKERMANN, KARL-AUGUST;RAUTENBERG, WILFRIED;LEIBROCK, JOACHIM;GREINER, HARTMUT;TOBE, TAKAHIKO |
| 分类号 |
A61P25/28;C07D231/12;C07D231/14;C07D401/04;C07D401/06;C07D403/06;C07D409/10;C07D417/06;C07D471/04;C07D491/10;(IPC1-7):C07D401/06;C07D401/14;A61K31/415 |
主分类号 |
A61P25/28 |
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