ANTI-MUSCARINIC AGENT AND ESTROGEN-AGONIST FOR TREATING UNSTABLE OR OVERACTIVE BLADDER

摘要

The invention relates to a method of treating unstable or overactive urinary bladder, wherein the method comprises administering to a patient in need of such treatment an antimuscarinic agent in a pharmaceutically effective amoun t thereof and ostrogen agonist in a pharmaceutically effective amount thereof. The antimuscarinic agent is preferebly tolterodine or a tolterodine-related compound. The invention also relates to a pharmaceutical formation containin g an antimuscarinic agent, estrogen agonist and pharmaceutically excipients an d the use of the combination for the manufacture of a therapeutical formulatio n for treating unstable or overactive urinary bladder.