| 摘要 |
The present invention provides novel polynucleotides encoding APEX4 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of APEX4 polypeptides, APEX4v1 and APEX4sv1, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel APEX4, APEX4v1, and APEX4sv1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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