METHODS FOR PREPARATION OF MACROCYCLIC MOLECULES MACROCYCLIC MOLECULES PREPARED THEREBY AND SUBSTRATES AND SOLID SUPPORTS FOR USE THEREIN
摘要
The invention features a new solid supports having at least one amino functionality and a linker bound to the solid support through at least a portion of the amino functional groups. The invention also features solid support bound substrates suitable for use in the formation of macrocycles by a TE domain catalyzed macrocyclization reaction. The invention features methods of making the solid supports and solid support bound substrates of the invention and methods of effecting macrocyclizations of solid support bound substrates. The invention further provides new macrocyclic molecules having one or more peptide domains and one or more polyketide domains in the macrocyclic ring. In another embodiment of the invention, libraries of macrocycles are provided as well as methods of forming libraries of macrocycles from libraries of solid support bound substrates are provided.
申请公布号
WO03040094(A2)
申请公布日期
2003.05.15
申请号
WO2002US35487
申请日期
2002.11.06
申请人
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人
WALSH, THOMAS, CHRISTOPHER;KOHLI, RAHUL, MANU;BURKART, MICHAEL, D.;BURKE, MARTIN, D.