ALLOGENIC VACCINE THAT CONTAINS A COSTIMULATORY POLYPEPTIDE-EXPRESSING TUMOR CELL

摘要

The invention relates to the use of a tumor cell for producing a vaccine for the treatment or prophylaxis of tumors in patients, said tumor cell expressi ng a costimulatory polypeptide and said tumor cell and said patient having non- identical MHC molecules. The invention further relates to the use of a costimulatory polypeptide-expressing tumor cell for producing a vaccine for increasing the lytic activity of NK cells in the treatment or prophylaxis of a tumor in a patient that is allogenic with respect to the tumor cell.