| 发明名称 |
POLYMERIC THIOL-LINKED PRODRUGS |
| 摘要 |
Thiol-linked polymeric prodrugs and methods of making and using the same are disclosed. The use of a sulfhydryl bond as the basic link for linking the polymer to the drug allows a prodrug to be formed which takes advantage of plasma enzymes in vivo. A preferred conjugate is. Methods of preparing and treatment are also disclosed.
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| 申请公布号 |
CA2465206(A1) |
申请公布日期 |
2003.05.15 |
| 申请号 |
CA20022465206 |
申请日期 |
2002.11.08 |
| 申请人 |
ENZON, INC. |
发明人 |
GREENWALD, RICHARD B.;CHOE, YUN HWANG |
| 分类号 |
A61K31/19;A61K31/198;A61K31/34;A61K31/401;A61K31/505;A61K31/7016;A61K31/7076;A61K47/48;A61P35/00;A61P35/02;A61P37/06;A61P43/00;C08F2/00;C08G63/46;C08G63/685;C08G63/688;(IPC1-7):C07H19/16;A61K9/14;C07D473/38;A61K39/395;A61K39/40;A61K39/42;A61K39/44;A61K31/74 |
主分类号 |
A61K31/19 |
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