| 发明名称 |
POLYAMIDE MODULATORS OF COX2 TRANSCRIPTION |
| 摘要 |
Processes and compositions are provided for regulating COX2 gene expression in a cell. The process includes selecting a polyamide composition comprising N- methyl pyrrole (Py) and N-methyl imidazole (Im) to provide specific binding to DNA at a COX2 gene target site in a cell. The polyamide is then combined wit h the cell containing the COX2 gene, wherein the polyamide binds to the COX2 gene promoter target site and regulates transcription of the COX2 gene.</SDO AB>
|
| 申请公布号 |
CA2466391(A1) |
申请公布日期 |
2003.05.15 |
| 申请号 |
CA20022466391 |
申请日期 |
2002.11.07 |
| 申请人 |
PHARMACIA CORPORATION |
发明人 |
BASHKIN, JAMES K.;SCHWEITZER, BARBARA A.;CROWLEY, KATHLEEN S.;PHILLION, DENNIS P.;WOODARD, SCOTT S.;BURNETTE, BARRY L. |
| 分类号 |
C12N15/09;A61K31/4025;A61K31/4178;A61K38/00;A61K48/00;A61P43/00;C07D207/30;C07D403/14;C07K14/575;C12N5/02;C12N15/63;(IPC1-7):C12N5/02;C07D231/02;C07D403/02 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
