DIASTEREOSELECTIVE PROCESS FOR THE PREPARATION OF THE ANTIVIRAL AGENT4-AMINO-1-(2R-HYDROXYMETHYL-[1,3]OXATHIOLAN-5S-YL)-1H-PYRIMIDIN-2-ONE

摘要

Process for the synthesis of 4-amino-1-(2R-hydroxymethyl - [1,3]oxathiolan-5S-yl)-1H-pyrimidin-2-one (LAMIVUDINE) comprising the reduction of 2-(R)-(4'-(R)acetonyl)-5-oxo-1,3-oxathiolan to give 2-(R)-(4'-(R)-acetonyl)-5-hydroxy-1,3-oxathiolan.