BAALC EXPRESSION AS A DIAGNOSTIC MARKER FOR ACUTE LEUKEMIA

摘要

Overexpression of the gene, BAALC, in biological samples from a patient is prognostic for tumor aggressiveness and unfavorable patient outcome. The present invention provides polynucleotides primers and probes for assaying for overexpression of BAALC transcripts. Kits containing the primers and probes are also provided. Also provided are antibodies for assaying for overexpression of BAALC proteins as well as peptide immunogens for producing the anti BAALC antibodes. The present invention also provides methods fo rcharacterizing acute myeologenous leukemia, chronic myelogenous leukemia and prostate cancer in a patient, base on detection of BAALC overexpression.