发明名称 |
WÄSSRIGE SUSPENSIONEN VON SUBMIKRON 9- HYDROXYRISPERIDON FETTSÄUREESTERN |
摘要 |
<p>The present invention is concerned with a pharmaceutical composition suitable as a depot formulation for administration via intramuscular or subcutaneous injection, comprising: (1) as an active ingredient a therapeutically effective amount of a 9-hydroxy-risperidone fatty acid ester or a salt, or a stereoisomer or a stereoisomeric mixture thereof in submicron form and (2) a pharmaceutically acceptable carrier; wherein the pharmaceutically acceptable carrier is water and the active ingredient is suspended therein and with a process of preparing such a composition. The invention further concerns such a pharmaceutical composition for use as a medicament in the treatment of psychosis, schizophrenia, schizoaffective disorders, non-schizophrenic psychoses, behavioural disturbances associated with neurodegenerative disorders, e.g. in dementia, behavioural disturbances in mental retardation and autism, Tourette's syndrome, bipolar mania, depression, anxiety.</p> |
申请公布号 |
AT239480(T) |
申请公布日期 |
2003.05.15 |
申请号 |
AT19980965159T |
申请日期 |
1998.11.10 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
FRANCOIS, MARC, KAREL, JOZEF;DRIES, WILLY, MARIA, ALBERT, CARLO;BASSTANIE, ESTHER, DINA, GUIDO |
分类号 |
C07D471/04;A61K9/08;A61K9/14;A61K31/505;A61K31/506;A61K31/517;A61K31/519;A61P25/00;A61P25/18;A61P25/22;A61P25/24;A61P25/28;(IPC1-7):A61K31/517 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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