摘要 |
<p>A process for producing an optically active 3,5-dihydroxyhexanoic acid derivative by stereoselectively reducing an optically active 3-oxo-5-hydroxyhexanoic acid derivative. It necessitates neither an ultralow-temperature reactor nor an incubator and is a simple and economical process in which protection of the 5-position hydroxy is unnecessary. Hydrogen, which is extremely inexpensive, is used as a reducing agent to asymmetrically hydrogenate an optically active 3-oxo-5-hydroxyhexanoic acid derivative by the catalytic action of a ruthenium/optically active phosphine complex, especially an RuBr2BINAP complex prepared from 2,2'-bisdiarylphosphino-1,1'-binaphthyl (BINAP) and a ruthenium complex, to thereby produce an optically active 3,5-dihydroxyhexanoic acid derivative.</p> |