NEUROGLOBIN IS UP-REGULATED BY AND PROTECTS NEURONSFROM HYPOXIC-ISCHEMIC INJURY

摘要

This invention pertains to the discovery that neuroglobin Ngb expression helps promote neuronal survival from hypoxic-ischemic insults. Neuroglobin thus provides a good target to screen for agents that mitigate harmful effects from hypoxic-/ischemic insult. Methods are provided for screening for agents that promote neuronal survival from hypoxic-ischemic insult e.g., ischaemic injury such as caused by myocardial infarction, stroke induced neuron death, reperfusion injury, traumatic head injury, cardiac arrest, asphyxiation, and the like.