| 发明名称 |
IL-21 ANTAGONISTS |
| 摘要 |
The polypeptides, and the polynucleotides encoding for them, described herein are IL-21 antagonists that bind with specificity and exhibit an EC50 that is not detectable in receptor binding studies. These molecules have mutations in the D helix of the IL-21 molecule, and can be used to inhibit the activity of IL-21 with its cognate receptor. |
| 申请公布号 |
WO03040313(A2) |
申请公布日期 |
2003.05.15 |
| 申请号 |
WO2002US34502 |
申请日期 |
2002.10.28 |
| 申请人 |
ZYMOGENETICS, INC |
发明人 |
PRESNELL, SCOTT, R.;WEST, JAMES, W.;NOVAK, JULIA, E. |
| 分类号 |
C12N15/09;A61K38/00;A61P35/00;A61P37/02;C07K14/54;C07K14/55;C07K14/715;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12P21/02;C12P21/04 |
主分类号 |
C12N15/09 |
| 代理机构 |
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