发明名称 |
ANTHRANILIC ACID AMIDES AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS |
摘要 |
The invention relates to anthranilic acid amide derivatives of formula (I), wherein R1 represents H or lower alkyl, R2 represents H or lower alkyl, R3 represents perfluoro lower alkyl, and X is O or S, or an N-oxide or a tautomer thereof, to salts of such anthranilic acid amides, their N-oxides and their tautomers; processes for the preparation thereof, the application thereof for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment especially of a neoplastic disease, such as a tumor disease, of retinopathy or age - related macular degeneration; a method for the treatment of such a disease in animals, especially in humans, and the use of such a compound-alone or in combination with one or more other pharmaceutically active compounds - for the manufacture of a pharmaceutical preparation for the treatment of a neoplastic disease, of retinopathy or age-related macular degeneration.
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申请公布号 |
WO03040102(A1) |
申请公布日期 |
2003.05.15 |
申请号 |
WO2002EP12444 |
申请日期 |
2002.11.07 |
申请人 |
NOVARTIS AG;NOVARTIS PHARMA GMBH;BOLD, GUIDO;FURET, PASCAL;MANLEY, PAUL, WILLIAM |
发明人 |
BOLD, GUIDO;FURET, PASCAL;MANLEY, PAUL, WILLIAM |
分类号 |
A61K31/44;A61K31/4412;A61P9/10;A61P9/14;A61P11/06;A61P15/00;A61P17/06;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P35/02;A61P43/00;C07D213/64;C07D213/70;(IPC1-7):C07D213/64 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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