发明名称 |
METHODS FOR INHIBITING PROLIFERATION OF ASTROCYTES AND ASTROCYTIC TUMOR CELLS AND FOR ENHANCING SURVIVAL OF NEURONS AND USES THEREOF |
摘要 |
The present invention provides methods for inhibiting proliferation of astrocytes and astrocytic tumor cells. The present invention further provide s methods for treating a condition associated with a defect in astrocyte proliferation in a subject, and methods for treating a condition associated with astrocytic tumor cell proliferation in a subject. Additionally, the present invention discloses methods for enhancing survival of neurons. The present invention still further provides methods for treating neural degeneration in a subject. The present invention is also directed to pharmaceutical compositions, comprising NrS1 protein or nucleic acid and a pharmaceutically-acceptable carrier. Finally, the present invention provides a purified NrS1 protein, an agent that binds to the NrS1 protein, a kit comprising an agent that binds to the NrS1 protein, and a composition comprising the NrS1 protein and a carrier. |
申请公布号 |
CA2466334(A1) |
申请公布日期 |
2003.05.15 |
申请号 |
CA20022466334 |
申请日期 |
2002.11.07 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY |
发明人 |
ZERLIN, MARIELBA;SUAREZ, CARLOS;WEINSTEIN, DAVID E. |
分类号 |
C12N15/09;A61K38/00;A61K38/17;A61K38/45;A61K48/00;A61P21/00;A61P21/04;A61P25/00;A61P25/14;A61P25/28;A61P27/02;A61P31/18;A61P43/00;C07K14/47;C07K14/705;C12Q1/02;(IPC1-7):C12N15/12;G01N33/566 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|