发明名称 |
PROPAGATION OF HUMAN HEPATOCYTES IN NON-HUMAN ANIMALS |
摘要 |
The present invention relates to the preparation of non-human animals having chimeric livers, whereby some or substantially all of the hepatocytes present are human hepatocytes. It is based, at least in part, on the discovery that rats, tolerized in utero against human hepatocytes, were found to serve as long-term hosts for human hepatocytes introduced post-natally, and the introduced hepatocytes maintained their differentiated phenotype, as evidenced by continued production of human albumin. |
申请公布号 |
EP1225801(A4) |
申请公布日期 |
2003.05.14 |
申请号 |
EP20000914822 |
申请日期 |
2000.03.03 |
申请人 |
THE UNIVERSITY OF CONNECTICUT |
发明人 |
WU, GEORGE, Y.;WU, CATHERINE, H. |
分类号 |
A01K67/027;A61K35/12;A61K35/407;A61K39/00;A61K48/00;A61P1/16;C12N5/071;C12N9/12;C12N9/72;C12N15/09;C12N15/113 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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