Pharmaceutical preparation containing pharmaceutically acceptable carrier or ointment excipient and acryloyl distamycin derivative and anti-microtubule agent and/or antimetabolite as active ingredients

摘要

The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha-bromo- and alpha-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and antimicrotubule agents. Also provided is the use of the said combination in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogcncsis.