发明名称 |
Stable polymorphous form of N-(3-ethynyl phenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, hydrochloride, processes of its preparation and pharmaceutical use thereof |
摘要 |
The present invention relates to crystalline forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, their production in essentially pure form, and their use. The invention also relates to the pharmaceutical compositions containing the crystalline forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound. |
申请公布号 |
CZ20022019(A3) |
申请公布日期 |
2003.05.14 |
申请号 |
CZ20020002019 |
申请日期 |
2000.11.09 |
申请人 |
OSI PHARMACEUTICALS, INC. |
发明人 |
CONNELL RICHARD D.;MOYER JAMES D.;MORIN MICHAEL J.;KAJIJI SHAMA M.;FOSTER BARBARA A.;FERRANTE KAREN J.;NORRIS TIMOTHY;RAGGON JEFFREY W.;SILBERMAN SANDRA L. |
分类号 |
A61K9/20;A61K31/505;A61K31/517;A61K38/45;A61K38/46;A61K38/55;A61K39/395;A61K45/00;A61K45/06;A61P9/10;A61P35/00;A61P37/02;A61P43/00;B01D9/02;C07D239/04;C07D239/94 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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