发明名称 |
8-substituted-9H-1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives, as AMPA/kainate receptor inhibitors |
摘要 |
The disclosure relates to a novel 8-substituted-9H-1,3-dioxolo-[4,5-h][2,3]benzodiazepine compound of formula I and pharmaceutically acceptable quaternary ammonium salts thereof, a process for preparing the same, a pharmaceutical composition containing a 8-substituted-9H-1,3-dioxolo-[4,5-h][2,3]benzodiazepine compound, and a method of treatment using the pharmaceutical composition. A complete description of the compound of formula I is found in the specification. The compounds of the general formula I possess unique competitive AMPA/kainite antagonist properties making them useful in the treatment of diseases where inhibition of the AMPA/kainite receptors may a favorable effect.
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申请公布号 |
US6562810(B1) |
申请公布日期 |
2003.05.13 |
申请号 |
US20000485391 |
申请日期 |
2000.05.19 |
申请人 |
EGIS GYOGYSZERGYAR RT. |
发明人 |
BALAZS LASZLO;BARKOCZY JOZSEF;DOMAN IMRE;EGYED ANDRAS;GACSALYI ISTVAEN;GIGLER GABOR;GREFF ZOLTAN;GYERTYAN ISTVAN;KOTAY NAGY PETER;KOVACS ATTILA;LAVAY GYOERGY;RATKAI ZOLTAN;SERES PETER;SIMIG GYULA;SIMO ANNAMARIA;SZABADOS TAMAS;SZABO GEZA;TIHANYI KAROLY;VEGH MIKLOS;SCHNEIDER GEZA;CSELENYAK JUDIT |
分类号 |
A61K31/551;A61P1/08;A61P21/02;A61P25/00;A61P25/06;A61P25/08;A61P25/28;C07D491/04;C07D491/056;(IPC1-7):A61K31/55;A61D25/08;C07D243/00 |
主分类号 |
A61K31/551 |
代理机构 |
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