发明名称 |
Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
摘要 |
Immunomodulatory oligonucleotide compositions are disclosed. These oligonucleotides comprise an immunostimulatory hexanucleotide sequence comprising a modified cytosine. These oligonucleotides can be administered in conjunction with an immunomodulatory peptide or antigen. Methods of modulating an immune response upon administration of the oligonucleotide comprising a modified immunostimulatory sequence are also disclosed.
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申请公布号 |
US6562798(B1) |
申请公布日期 |
2003.05.13 |
申请号 |
US19990324191 |
申请日期 |
1999.06.01 |
申请人 |
DYNAVAX TECHNOLOGIES CORP. |
发明人 |
SCHWARTZ DAVID |
分类号 |
A61K39/39;A61K47/48;A61P37/04;C07H21/00;C12N15/117;(IPC1-7):A01N43/04;C12Q1/68;C12P19/34;C12N5/00;C07H21/02 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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