| 摘要 |
PROBLEM TO BE SOLVED: To provide human NHE2 polynucleotides and the polypeptide sequences and to provide an assay method for identifying agents for modulating NHE2 activity. SOLUTION: The invention provides two forms of isolated or purified human NHE2 polypeptide sequences, NHE2-LF and NHE2-SF, as well as the polynucleotide coding sequences that encode the human NHE2-LF and NHE2-SF polypeptides. NHE2-LF- and NHE2-SF-related hosts, cell membrane preparations, vectors, and antibodies, as well as methods for identifying agents that modulate human NHE activity by using cells recombinantly expressing the human NHE2- LF or NHE2-SF are also provided. |
